HIV Pathogenesis, Fitness and Resistance Session Posters
High rates of HIV-1 recombination
in T cells
W-S Hu
HIV-1 populations are large, highly
diverse, and characterized by frequent recombination in drug-naive and drug-resistant
individuals
F Maldarelli
Evidence of differential selection
of HIV-1 variants carrying drug-resistant mutations in seroconverters
C Balotta
Evolution of resistance mutations
acquired at time of primary infection: persistence in circulating and archived
HIV strains
ML Chaix
Transmitted
NNRTI drug resistance is associated with higher steady-state viral load measures
in untreated subjects with primary HIV infection
SJ Little
Distinct patterns of selection and fading of K103N and Y181C are seen in women
with subtype A vs D HIV-1 after single dose nevirapine:
HIVNET 012
SH Eshleman
Wild-type fitness of subtype C
HIV-1 isolates containing multiple drug-resistant mutations in reverse transcriptase
is due to compensation at the viral entry step
EJ Arts
A novel method based on recombinant
viruses expressing green (EGFP) or red (DsRED) fluorescent proteins to study
replicative fitness evolution of nelfinavir-resistant HIV-1 harbouring D30N
and L90M mutations in the protease gene
J Weber
Relationship between low replication
capacity and protease inhibitor hypersusceptibility in >3000 clinical samples
lacking protease inhibitor resistance mutations
M Bates
Replication
capacity explains the persistence of drug-resistant protease mutants in vivo
after transmission or partial treatment interruption
NM van Maarseveen
Replicative fitness evolution
of a nelfinavir-resistant HIV-1 strain in the presence of different protease
inhibitors
ME Quiñones-Mateu
Effect of RT resistance mutations
on viral replication in hydroxyurea-pretreated cells
AJ Hance
Fitness of T215Y versus T215F
mutants in HIV-1 RT: comparison of specific thymidine analogue resistance mutation
(TAM) patterns
ZX Hu
The Q207D reverse transcriptase
mutation decreases zidovudine susceptibility and increases relative fitness
of zidovudine-resistant human immunodeficiency virus type 1
J Lu
Replicative fitness of HIV-1 strains
with reduced susceptibility to protease-, reverse transcriptase- and entry (enfuvirtide)-inhibitors
ME Quiñones-Mateu
Reduced HIV replication capacity is associated with improved CD4 reconstitution
following suppressive HAART
C Hicks
Very low levels of plasma HIV-1
viraemia in subjects with sustained suppression of viraemia <50 copies/ml
can influence the recovery of CD4 cell counts after initiating HAART promoting
the occurrence of transient viraemic episodes
V Calvez
CD8 T cell recognition of HIV-1
RT mutations induced by therapy with RT inhibitors in HIV-infected patients
with persistent low viral load
A Samri
Selection pressure by neutralizing
antibodies results in higher adaptive mutation rates in gp120
HF Günthard
Evolution of NRTI resistance patterns
in heavily pre-treated HIV-1-infected patients undergoing treatment interruption
R Kaiser
Targeting reservoirs of human
immunodeficiency virus infection: inducing latent viral expression without host
cell activation
DM Margolis
Expression of APOBEC3G varies
across individuals, in different HIV host cells, and with immunological activation
MP De Pasquale
Isolated
lopinavir resistance after virological rebound of a lopinavir/ritonavir-based
regimen
SG Deeks
Surveillance of resistance in
KZN South Africa, including mother-infant pairs 6 weeks after single-dose NVP
M Gordon
A
novel 5 amino acid insertion in the ß3-ß4 loop of HIV-1 RT conferring
only low-level multidrug resistance
MCDG Huigen
Phylogeny
and resistance profile of HIV-1 POL sequences obtained from rectal biopsies
and blood
AB Petersen
Evolution
of human immunodeficiency virus type-1 variants resistant to protease inhibitors
after a protease inhibitor-sparing regimen
N Gianotti
Impact of the M184V/I
on protease inhibitor susceptibilities in protease inhibitor-naive patients
NS Shulman
