December 4-8, 2011

Grand Hyatt Kauai

Koloa, Hawaii

Scientific Program: Confirmed Speakers


Click here to view the Final Program and Abstract Book
Click here to view the Satellite Mini-symposium Final Program
Click here to view Selected Presentations

HEP DART 2011 SATELLITE MINI-SYMPOSIUM

Curative Therapies for HCV: Resistance is Futile
Sunday, December 4, 2011
9:00 AM – 1:00 PM, followed by luncheon
Open to all registered HEP DART 2011 delegates

Advances in HCV viral load testing
Gavin Cloherty; Abbott Molecular, USA

Multiple approaches for a common goal
Douglas Dieterich; Mount Sinai School of Medicine, USA

Gaps in future HCV therapies
Michael Fried; University of North Carolina at Chapel Hill, USA

Resistance in the age of HCV protease inhibitor/pegIFN/RBV therapy
Ann Kwong; Vertex Pharmaceuticals, USA

The host targeting cyclophilin inhibitor alisporivir presents a high barrier to resistance both in vitro and in HCV patients with no cross-resistance to DAAs
Kai Lin; Novartis, USA

Combination DAA strategies to cure HCV
Douglas Mayers; Idenix Pharmaceuticals, USA

Interferon free therapy for HCV
David Nelson; University of Florida, USA

Boceprevir in the era of DAA
Fred Poordad; Cedars-Sinai Medical Center, USA


WILLIAM H. PRUSOFF HEP DART LIFETIME ACHIEVEMENT AWARD LECTURE
The HEP DART Organizing Committee recognizes that every scientific and medical advance relies on the strong foundations of discoveries by those who have come before us. Instituted in 2005, the William H. Prusoff HEP DART Lifetime Achievement Award is given at each HEP DART conference to a researcher who has made integral contributions over their career toward the advancement of care of persons infected with hepatitis viruses.

  This year’s recipient:
Robert H. Purcell; NIAID, National Institutes of Health, USA
Dr. Purcell is the author of more than 600 publications and a member of the National Academy of Sciences.

STATE OF THE ART PRESENTATIONS
Exploitation of Host Cell Targets for HCV-specific Therapy
Ralf Bartenschlager; University of Heidelberg, Germany

Hepatitis Viruses: Evolution and Diversity
R. Palmer Beasley; Ashbel Smith Professor at The University of Texas School of Public Health, USA

The Future of HCV Therapy in Non-genotype 1 Patients
Marc Bourlière; Fondation Hôpital Saint Joseph, France

IL28B - Impact on Treatment Decisions
Michael Fried; University of North Carolina at Chapel Hill, USA

Best Targets for Antifibrotic Therapy
Scott Friedman; Mount Sinai School of Medicine, USA

HBV and HCV Antiviral Drug Resistance: Prevention and Monitoring
Stephen Locarnini; VIDRL, Australia

New In Vitro and In Vivo Preclincal Models for HCV Drug Discovery
Charles Rice; The Rockefeller University, USA

Turning Despair into Hope: Ripples becoming Tsunamis
Eugene Schiff; University of Miami, USA

HCV and the Central Nervous System
Howard Thomas; Imperial College, UK


Strategies for Improving Early Identification of Patients with Chronic Viral Hepatitis
Miriam Alter; University of Texas Medical Branch at Galveston, USA

Hepatitis B Foundation Symposium Debate: Are New Drugs Needed to Prevent HBV?
Timothy Block; Hepatitis B Foundation and Drexel University College of Medicine, USA (Moderator)
Frank Chisari; The Scripps Research Institute, USA (Co-moderator)
Adrian DiBisceglie; Saint Louis University School of Medicine, USA
Jules Dienstag; Harvard Medical School, USA
Brian McMahon; Alaska Native Medical Center, USA
David Thomas; Johns Hopkins University School of Medicine, USA

Intercellular Exosomal Transfer of HCV RNA to Plasmacytoid Dendritic Cells Triggers the Innate Response
Frank Chisari; The Scripps Research Institute, USA

Boceprevir and Telaprevir: Benefits and Limitations
Jules Dienstag; Harvard Medical School, USA

Panel Discussion: The Business of Antiviral Agents: Paying for Performance
Abel De La Rosa; Pharmasset, USA (Moderator)
David Witzke; PioneerPath Capital, USA (Moderator)

Poster Overviews
Adrian Di Bisceglie; Saint Louis University School of Medicine, USA
Adrian Ray; Gilead Sciences, Inc., USA

Will Lambda Interferon replace Pegs?
Douglas Dieterich; Mount Sinai School of Medicine, USA

Autophagy Machinery is Required to Initiate Hepatitis C Virus Replication
Marlène Dreux; The Scripps Research Institute, USA

Complete Replication Cycle Screening for Antiviral Discovery
Juliane Gentzsch; Twincore, Germany

Role of DAA in persons considered for liver transplantation
Ira Jacobson; Weill Cornell Medical College, USA

Mechanism of action of nitazoxanide
Brent Korba; Georgetown University, USA

TLR7: A Therapeutic Target for HBV and HCV Chronic Infections
Robert Lanford; Texas Biomedical Research Institute, USA

Fitness of protease inhibitor-resistant HCV variants
Stanley Lemon; University of North Carolina at Chapel Hill, USA

Eradication of HBV: Can We Eliminate cccDNA?
Massimo Levrero; Sapienza Università di Roma, Italy

Intrinsic Innate Immunity and HCV Infection
T. Jake Liang; NIDDK, National Institutes of Health, USA

HCV NS5A Inhibitors
Anna Lok; University of Michigan Medical Center, USA

HBV therapy: The role of quantitative HBsAg and cccDNA in future therapies
Patrick Marcellin; Hôpital Beaujon, France

Molecular Targeting Therapy for Our Patients with HCC
Masao Omata; University of Tokyo, Yamanashi Central Hospital, Japan

HCV viral kinetics in the age of DAAs
Alan Perelson; Los Alamos National Laboratory, USA

HIV/HCV Co-infected People: What are the Specific Concerns Co-infected People Face?
Marion Peters; University of California, San Francisco, USA

Management of Hepatitis C in the Era of DAA: Lessons Learned from Failed Studies
Paul Pockros; The Scripps Clinic, USA

The Status of Noninvasive Tests for Hepatic Fibrosis
Thierry Poynard; Groupe Hospitalier Pitie-Salpétriére, France

Roles of virus-host interaction in replication and pathogenesis of HCV
Glenn Randall; The University of Chicago, USA

Consensus Recommendation on Treatment of Acute HCV in HIV+ People, Ideas for Trials
Jürgen Rockstroh; University of Bonn, Germany

Acute hepatitis C infection in HIV-infected patients
Kenneth Sherman; University of Cincinnati College of Medicine, USA

Safety and Efficacy of PR+DAA in HCV/HIV Co-infected Patients
Mark Sulkowski; Johns Hopkins University, USA

Hepatitis B Foundation Symposium Debate: HCV, HBV, HIV and health care workers: updating guidelines in the age of antiviral agents
Tracy Swan; Treatment Action Group, USA (Moderator)
Joan Block; Hepatitis B Foundation, USA (Co-moderator)
Jules Levin; NATAP, USA
Anna Lok; University of Michigan Medical Center, USA
David Thomas; Johns Hopkins University School of Medicine, USA
John Ward; Centers for Disease Control and Prevention, USA

Special Lecture: Re-emergence of HDV
John Taylor; Fox Chase Cancer Center, USA

Hepatitis C Pharmacogenomics
David Thomas; Johns Hopkins, USA

Identification, Screening and Surveillance of HCV Infections in the Era of Improved Therapy for Hepatitis C
John Ward; Centers for Disease Control and Prevention, USA

Impact and Implementation of the WHO Resolution for Viral Hepatitis
Steve Wiersma; World Health Organization, Switzerland

Antiviral HBV Assembly Effectors (AEs): Mechanisms and Implications for Eradication
Adam Zlotnick; Indiana University, USA

Addressing an epidemic: San Francisco Hep B Free
Janet Zola; San Francisco Dept. of Public Health, USA



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